Bündchen has been the face of a variety of advertising campaigns including several seasons of Christian Dior, Louis Vuitton, and Victoria's Secret. She has appeared in advertisements for Nivea lotion and is the face of several Brazilian brands including Vivo, Multiplan (Shopping Malls), Colcci, Credicard (Citibank) and Volkswagen do Brasil. After C&A Brazil hired Bündchen as a spokesmodel and began airing television commercials, sales increased by 30%.
In May 2006, Bündchen signed a multi-million dollar deal with American giant Apple Inc.. She starred in an advertising campaign to promote the new Macintosh line through the Get a Mac advertisements. Also in 2006, Bündchen became the new face of Swiss luxury watchmaker Ebel.
IN 2001 Gisele launched her best-selling flip-flop line, Ipanema by Gisele Bundchen; in just three years, sales topped $30 million, with a portion of proceeds going to green causes.
She has her own line of sandals with footwear company Grendene called Ipanema Gisele Bündchen. Forbes puts her 53rd on their list of the most powerful celebrities of 2007 because of the international success of her shoe line, making the brand Ipanema the most sold Brazilian flip-flop in the world, surpassing the legendary Havaianas. Custom Ipanema flip-flops sell for as much as $230 a pair. She is also the owner of a hotel in the south of Brazil, the Palladium Executive.
On 1 May 2007, it was announced that Bündchen had ended her contract with Victoria's Secret. Shares of its parent company, Limited Brands, reportedly fall 31.5 percent.
In July 2007, having earned an estimated total of $33 million in the previous 12 months, Forbes magazine named her the world's top-earning model in the list of the World's 15 Top-Earning Supermodels.
An American economist named Fred Fuld developed a stock index to measure the profit performance improvement of companies represented by Bündchen compared with the Dow Jones Industrial Average. According to Fuld, the Gisele Bündchen Stock Index was up 15% between May and July 2007, substantially surpassing the Dow Jones Industrial Average which was up just 8.2%.
By 2008 With annual income now topping $35 million, she continues to dominate the Forbes list of the world’s highest-earning models, and also holds steady on the magazine’s list of the Top 20 Richest Women in Entertainment.
During 2009–2010, she was reportedly the top earning supermodel, earning an estimated $25 million.
In 2010 Despite her pregnancy the previous year, she still retains the top spot as Forbes’s highest-earning model, with a take-home pay of $25 million.
In 2010 Gisele introduced her own Skin care line, named Sejaa Pure Skincare.
Edward Razek, chief marketing officer of Limited Brands, who worked with Bündchen during her Victoria's Secret career says, "She's an international icon who can also move product—from shampoo to couture."
On May Forbes ranked her, for the fifth consecutive time, as the world's top-earning model with an estimated $45 million over the past 12 months (2010–2011). Her earnings climbed $20 million over the previous year, thanks to an economic boom in her homeland of Brazil coupled with a 10% surge in the value of the Brazilian real against the dollar.
The Lingerie Brand "HOPE" of which Gisele has been contracted since 2010 discovered the power of Gisele to stimulate business. The company saw the search for its products duplicate in just two months, resulted, says the commercial director Carlos Eduardo Padula, of the visibility generated by the launch of Gisele's personal lingerie collection the Gisele Bundchen Brazilian Intimates. The sales in "The Day of the Boyfriends" also saw growth in 2011 by 25% in comparison with 2010, when it did not yet have Gisele representing the brand. Upon hiring Gisele for Hope since 2010, it's been reported she has made the invoicing of the company grow by 40%.